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Review Article| Volume 50, ISSUE 1, P17-29, March 2023

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Neonatal Opioid Withdrawal Syndrome

An Update on Developmental Outcomes

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      References

        • Honein M.A.
        • Boyle C.
        • Redfield R.R.
        Public health surveillance of prenatal opioid exposure in mothers and infants.
        Pediatrics. 2019; 143
        • Leech A.A.
        • Cooper W.O.
        • McNeer E.
        • et al.
        Neonatal abstinence syndrome in the United States, 2004-16.
        Health Aff (Millwood). 2020; 39: 764-767
        • Jilani S.M.
        • Jones H.E.
        • Grossman M.
        • et al.
        Standardizing the clinical definition of opioid withdrawal in the neonate.
        J Pediatr. 2022; 243: 33-39 e31
        • Blount T.
        • Painter A.
        • Freeman E.
        • et al.
        Reduction in length of stay and morphine use for NAS with the "eat, sleep, console" method.
        Hosp Pediatr. 2019; 9: 615-623
        • Pahl A.
        • Young L.
        • Buus-Frank M.E.
        • et al.
        Non-pharmacological care for opioid withdrawal in newborns.
        Cochrane Database Syst Rev. 2020; 12: CD013217
        • Hall E.S.
        • McAllister J.M.
        • Wexelblatt S.L.
        Developmental disorders and medical complications among infants with subclinical intrauterine opioid exposures.
        Popul Health Manag. 2019; 22: 19-24
        • Leyenaar J.K.
        • Schaefer A.P.
        • Wasserman J.R.
        • et al.
        Infant mortality associated with prenatal opioid exposure.
        JAMA Pediatr. 2021; 175: 706-714
        • Jones H.E.
        • Kaltenbach K.
        • Benjamin T.
        • et al.
        Prenatal opioid exposure, neonatal abstinence syndrome/neonatal opioid withdrawal syndrome, and later child development research: shortcomings and solutions.
        J Addict Med. 2019; 13: 90-92
        • Konijnenberg C.
        Methodological issues in assessing the impact of prenatal drug exposure.
        Subst Abuse. 2015; 9: 39-44
        • Singal D.
        • Chateau D.
        • Struck S.
        • et al.
        In Utero antidepressants and neurodevelopmental outcomes in kindergarteners.
        Pediatrics. 2020; 145: e20191157
        • Jacobson J.L.
        • Akkaya-Hocagil T.
        • Ryan L.M.
        • et al.
        Effects of prenatal alcohol exposure on cognitive and behavioral development: findings from a hierarchical meta-analysis of data from six prospective longitudinal U.S. cohorts.
        Alcohol Clin Exp Res. 2021; 45: 2040-2058
        • Salzwedel A.P.
        • Grewen K.M.
        • Vachet C.
        • et al.
        Prenatal drug exposure affects neonatal brain functional connectivity.
        J Neurosci. 2015; 35: 5860-5869
        • Corsi D.J.
        • Donelle J.
        • Sucha E.
        • et al.
        Maternal cannabis use in pregnancy and child neurodevelopmental outcomes.
        Nat Med. 2020; 26: 1536-1540
        • Wong H.S.
        • Santhakumaran S.
        • Cowan F.M.
        • et al.
        Medicines for neonates investigator G. Developmental assessments in preterm children: a meta-analysis.
        Pediatrics. 2016; 138
        • Boggess T.
        • Risher W.C.
        Clinical and basic research investigations into the long-term effects of prenatal opioid exposure on brain development.
        J Neurosci Res. 2020; 100: 396-409
        • Merhar S.L.
        • Kline J.E.
        • Braimah A.
        • et al.
        Prenatal opioid exposure is associated with smaller brain volumes in multiple regions.
        Pediatr Res. 2020; 90: 397-402
        • Hartwell M.L.
        • Croff J.M.
        • Morris A.S.
        • et al.
        Association of prenatal opioid exposure with precentral gyrus volume in children.
        JAMA Pediatr. 2020; 174: 893-896
        • Merhar S.L.
        • Parikh N.A.
        • Braimah A.
        • et al.
        White matter injury and structural anomalies in infants with prenatal opioid exposure.
        AJNR Am J Neuroradiol. 2019; 40: 2161-2165
        • Monnelly V.J.
        • Anblagan D.
        • Quigley A.
        • et al.
        Prenatal methadone exposure is associated with altered neonatal brain development.
        Neuroimage Clin. 2018; 18: 9-14
        • Jiang W.
        • Merhar S.L.
        • Zeng Z.
        • et al.
        Neural alterations in opioid-exposed infants revealed by edge-centric brain functional networks.
        Brain Commun. 2022; 4: fcac112
        • Radhakrishnan R.
        • Vishnubhotla R.V.
        • Guckien Z.
        • et al.
        Thalamocortical functional connectivity in infants with prenatal opioid exposure correlates with severity of neonatal opioid withdrawal syndrome.
        Neuroradiology. 2022; 64: 1649-1659
        • Radhakrishnan R.
        • Vishnubhotla R.V.
        • Zhao Y.
        • et al.
        Global brain functional network connectivity in infants with prenatal opioid exposure.
        Front Pediatr. 2022; 10: 847037
        • Benninger K.L.
        • Peng J.
        • Ho M.L.
        • et al.
        Cerebral perfusion and neurological examination characterise neonatal opioid withdrawal syndrome: a prospective cohort study.
        Arch Dis Child Fetal Neonatal Ed. 2021; 107: 414-420
        • Bakhireva L.N.
        • Holbrook B.D.
        • Shrestha S.
        • et al.
        Association between prenatal opioid exposure, neonatal opioid withdrawal syndrome, and neurodevelopmental and behavioral outcomes at 5-8 months of age.
        Early Hum Dev. 2019; 128: 69-76
        • Labella M.H.
        • Eiden R.D.
        • Tabachnick A.R.
        • et al.
        Infant neurodevelopmental outcomes of prenatal opioid exposure and polysubstance use.
        Neurotoxicol Teratol. 2021; 86: 107000
        • McGlone L.
        • Mactier H.
        Infants of opioid-dependent mothers: neurodevelopment at six months.
        Early Hum Dev. 2015; 91: 19-21
        • Beckwith A.M.
        • Burke S.A.
        Identification of early developmental deficits in infants with prenatal heroin, methadone, and other opioid exposure.
        Clin Pediatr (Phila). 2015; 54: 328-335
        • Burke S.
        • Beckwith A.M.
        Morphine versus methadone treatment for neonatal withdrawal and impact on early infant development.
        Glob Pediatr Health. 2017; 4 (2333794X17721128)
        • Benninger K.L.
        • Borghese T.
        • Kovalcik J.B.
        • et al.
        Prenatal exposures are associated with worse neurodevelopmental outcomes in infants with neonatal opioid withdrawal syndrome.
        Front Pediatr. 2020; 8: 462
        • Merhar S.L.
        • McAllister J.M.
        • Wedig-Stevie K.E.
        • et al.
        Retrospective review of neurodevelopmental outcomes in infants treated for neonatal abstinence syndrome.
        J Perinatol. 2018; 38: 587-592
        • Serino Ma D.
        • Peterson Md BS.
        • Rosen Md TS.
        Psychological functioning of women taking illicit drugs during pregnancy and the growth and development of their offspring in early childhood.
        J Dual Diagn. 2018; 14: 158-170
        • Czynski A.J.
        • Davis J.M.
        • Dansereau L.M.
        • et al.
        Neurodevelopmental outcomes of neonates randomized to morphine or methadone for treatment of neonatal abstinence syndrome.
        J Pediatr. 2020; 219: 146-151 e141
        • Kaltenbach K.
        • O'Grady K.E.
        • Heil S.H.
        • et al.
        Prenatal exposure to methadone or buprenorphine: early childhood developmental outcomes.
        Drug Alcohol Depend. 2018; 185: 40-49
        • Levine T.A.
        • Woodward L.J.
        Early inhibitory control and working memory abilities of children prenatally exposed to methadone.
        Early Hum Dev. 2018; 116: 68-75
        • Lee S.J.
        • Pritchard V.E.
        • Austin N.C.
        • et al.
        Health and neurodevelopment of children born to opioid-dependent mothers at school entry.
        J Dev Behav Pediatr. 2020; 41: 48-57
        • Wouldes T.A.
        • Woodward L.J.
        Neurobehavior of newborn infants exposed prenatally to methadone and identification of a neurobehavioral profile linked to poorer neurodevelopmental outcomes at age 24 months.
        PLoS One. 2020; 15: e0240905
        • Kim H.M.
        • Bone R.M.
        • McNeill B.
        • et al.
        Preschool language development of children born to women with an opioid use disorder.
        Children. 2021; 8
        • Levine T.A.
        • Davie-Gray A.
        • Kim H.M.
        • et al.
        Prenatal methadone exposure and child developmental outcomes in 2-year-old children.
        Dev Med Child Neurol. 2021; 63: 1114-1122
        • Lee S.J.
        • Woodward L.J.
        • Henderson J.M.T.
        Educational achievement at age 9.5 years of children born to mothers maintained on methadone during pregnancy.
        PLoS One. 2019; 14: e0223685
        • Jaekel J.
        • Kim H.M.
        • Lee S.J.
        • et al.
        Emotional and behavioral trajectories of 2 to 9 Years old children born to opioid-dependent mothers.
        Res Child Adolesc Psychopathol. 2021; 49: 443-457
        • Konijnenberg C.
        • Sarfi M.
        • Melinder A.
        Mother-child interaction and cognitive development in children prenatally exposed to methadone or buprenorphine.
        Early Hum Dev. 2016; 101: 91-97
        • Konijnenberg C.
        • Melinder A.
        Executive function in preschool children prenatally exposed to methadone or buprenorphine.
        Child Neuropsychol. 2015; 21: 570-585
        • Fill M.-M.A.
        • Miller A.M.
        • Wilkinson R.H.
        • et al.
        Educational disabilities among children born with neonatal abstinence syndrome.
        Pediatrics. 2018; 142
        • Oei J.L.
        • Melhuish E.
        • Uebel H.
        • et al.
        Neonatal abstinence syndrome and high school performance.
        Pediatrics. 2017; 139: e20162651
        • Flannery T.
        • Davis J.M.
        • Czynski A.J.
        • et al.
        Neonatal abstinence syndrome severity index predicts 18-month neurodevelopmental outcome in neonates randomized to morphine or methadone.
        J Pediatr. 2020; 227: 101-107 e101
        • Bier J.B.
        • Finger A.S.
        • Bier B.A.
        • et al.
        Growth and developmental outcome of infants with in-utero exposure to methadone vs buprenorphine.
        J Perinatol. 2015; 35: 656-659
        • Sundelin Wahlsten V.
        • Sarman I.
        Neurobehavioural development of preschool-age children born to addicted mothers given opiate maintenance treatment with buprenorphine during pregnancy.
        Acta Paediatr. 2013; 102: 544-549
        • Whitham J.N.
        • Spurrier N.J.
        • Baghurst P.A.
        • et al.
        Visual evoked potential latencies of three-year-old children prenatally exposed to buprenorphine or methadone compared with non-opioid exposed children: the results of a longitudinal study.
        Neurotoxicol Teratol. 2015; 52: 17-24
        • Lambert J.E.
        • Peeler C.E.
        Visual and oculomotor outcomes in children with prenatal opioid exposure.
        Curr Opin Ophthalmol. 2019; 30: 449-453
        • McGlone L.
        • Hamilton R.
        • McCulloch D.L.
        • et al.
        Neonatal visual evoked potentials in infants born to mothers prescribed methadone.
        Pediatrics. 2013; 131: e857-e863
        • McGlone L.
        • Hamilton R.
        • McCulloch D.L.
        • et al.
        Visual outcome in infants born to drug-misusing mothers prescribed methadone in pregnancy.
        Br J Ophthalmol. 2014; 98: 238-245
        • Whitham J.N.
        • Spurrier N.J.
        • Sawyer M.G.
        • et al.
        The effects of prenatal exposure to buprenorphine or methadone on infant visual evoked potentials.
        Neurotoxicol Teratol. 2010; 32: 280-288
        • Walhovd K.B.
        • Bjørnebekk A.
        • Haabrekke K.
        • et al.
        Child neuroanatomical, neurocognitive, and visual acuity outcomes with maternal opioid and polysubstance detoxification.
        Pediatr Neurol. 2015; 52 (e321-323): 326-332
        • Gill A.C.
        • Oei J.
        • Lewis N.L.
        • et al.
        Strabismus in infants of opiate-dependent mothers.
        Acta Paediatr. 2003; 92: 379-385
        • Gupta M.
        • Mulvihill A.O.
        • Lascaratos G.
        • et al.
        Nystagmus and reduced visual acuity secondary to drug exposure in utero: long-term follow-up.
        J Pediatr Ophthalmol Strabismus. 2012; 49: 58-63
        • Hamilton R.
        • McGlone L.
        • MacKinnon J.R.
        • et al.
        Ophthalmic, clinical and visual electrophysiological findings in children born to mothers prescribed substitute methadone in pregnancy.
        Br J Ophthalmol. 2010; 94: 696-700
        • Mulvihill A.O.
        • Cackett P.D.
        • George N.D.
        • et al.
        Nystagmus secondary to drug exposure in utero.
        Br J Ophthalmol. 2007; 91: 613-615
        • Auger N.
        • Rheaume M.A.
        • Low N.
        • et al.
        Impact of prenatal exposure to opioids, cocaine, and cannabis on eye disorders in children.
        J Addict Med. 2020; 14: 459-466
        • Yang Y.
        • Wang C.
        • Gan Y.
        • et al.
        Maternal smoking during pregnancy and the risk of strabismus in offspring: a meta-analysis.
        Acta Ophthalmol. 2019; 97: 353-363
        • Melinder A.
        • Konijnenberg C.
        • Sarfi M.
        Deviant smooth pursuit in preschool children exposed prenatally to methadone or buprenorphine and tobacco affects integrative visuomotor capabilities.
        Addiction. 2013; 108: 2175-2182
        • Konijnenberg C.
        • Melinder A.
        Visual selective attention is impaired in children prenatally exposed to opioid agonist medication.
        Eur Addict Res. 2015; 21: 63-70
        • Uebel H.
        • Wright I.M.
        • Burns L.
        • et al.
        Reasons for rehospitalization in children who had neonatal abstinence syndrome.
        Pediatrics. 2015; 136: e811-e820
        • Milliren C.E.
        • Melvin P.
        • Ozonoff A.
        Pediatric hospital readmissions for infants with neonatal opioid withdrawal syndrome, 2016-2019.
        Hosp Pediatr. 2021; 11: 979-988
        • Shrestha S.
        • Roberts M.H.
        • Maxwell J.R.
        • et al.
        Post-discharge healthcare utilization in infants with neonatal opioid withdrawal syndrome.
        Neurotoxicol Teratol. 2021; 86: 106975
        • Percy Z.
        • Brokamp C.
        • McAllister J.M.
        • et al.
        Subclinical and overt newborn opioid exposure: prevalence and first-year healthcare utilization.
        J Pediatr. 2020; 222: 52-58.e51
        • Skurtveit S.
        • Nechanská B.
        • Handal M.
        • et al.
        Hospitalization of children after prenatal exposure to opioid maintenance therapy during pregnancy: a national registry study from the Czech Republic.
        Addiction. 2019; 114: 1225-1235
        • Kelty E.
        • Hulse G.
        A retrospective cohort study of the health of children prenatally exposed to methadone, buprenorphine or naltrexone compared with non-exposed control children.
        Am J Addict. 2017; 26: 845-851
        • Mahic M.
        • Hernandez-Diaz S.
        • Wood M.
        • et al.
        In Utero opioid exposure and risk of infections in childhood: a multinational Nordic cohort study.
        Pharmacoepidemiol Drug Saf. 2020; 29: 1596-1604
        • McAllister J.M.
        • Hall E.S.
        • Hertenstein G.E.R.
        • et al.
        Torticollis in infants with a history of neonatal abstinence syndrome.
        J Pediatr. 2018; 196: 305-308
        • Towers C.V.
        • Knapper A.
        • Gaylord M.
        • et al.
        Torticollis in infants with neonatal abstinence syndrome.
        J Perinatol. 2021; 41: 615-618
        • Boere-Boonekamp M.M.
        • van der Linden-Kuiper L.L.
        Positional preference: prevalence in infants and follow-up after two years.
        Pediatrics. 2001; 107: 339-343