Advertisement
Review Article| Volume 49, ISSUE 1, P267-277, March 2022

Controversies in Fetal Surgery

Prenatal Repair of Myelomeningocele in the Modern Era
Published:January 21, 2022DOI:https://doi.org/10.1016/j.clp.2021.11.015

      Keywords

      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'

      Subscribers receive full online access to your subscription and archive of back issues up to and including 2002.

      Content published before 2002 is available via pay-per-view purchase only.

      Subscribe:

      Subscribe to Clinics in Perinatology
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect

      References

        • Jancelewicz T.
        • Harrison M.R.
        A history of fetal surgery.
        Clin Perinatol. 2009; 36 (vii. (In eng)): 227-236
        • Kitagawa H.
        • Pringle K.C.
        Fetal surgery: a critical review.
        Pediatr Surg Int. 2017; 33: 421-433
        • Baumgarten H.D.
        • Flake A.W.
        Fetal surgery.
        Pediatr Clin North Am. 2019; 66 (In eng): 295-308
        • Adzick N.S.
        • Sutton L.N.
        • Crombleholme T.M.
        • et al.
        Successful fetal surgery for spina bifida.
        Lancet. 1998; 352: 1675-1676
        • Adzick N.S.
        • Thom E.A.
        • Spong C.Y.
        • et al.
        A randomized trial of prenatal versus postnatal repair of myelomeningocele.
        N Engl J Med. 2011; 364: 993-1004
        • Winder F.M.
        • Vonzun L.
        • Meuli M.
        • et al.
        Maternal complications following open fetal myelomeningocele repair at the Zurich center for fetal diagnosis and therapy.
        Fetal Diagn Ther. 2019; 46 (In eng): 153-158
        • Licci M.
        • Guzman R.
        • Soleman J.
        Maternal and obstetric complications in fetal surgery for prenatal myelomeningocele repair: a systematic review.
        Neurosurg Focus. 2019; 47 (In eng): E11
        • Kahr M.K.
        • Winder F.M.
        • Vonzun L.
        • et al.
        Open intrauterine fetal myelomeningocele repair: changes in the surgical procedure and perinatal complications during the first 8 years of experience at a single center.
        Fetal Diagn Ther. 2020; 47 (In eng): 485-490
        • Flake A.W.
        Prenatal intervention: ethical considerations for life-threatening and non-life-threatening anomalies.
        Semin Pediatr Surg. 2001; 10: 212-221
        • Elbabaa S.K.
        • Gildehaus A.M.
        • Pierson M.J.
        • et al.
        First 60 fetal in-utero myelomeningocele repairs at Saint Louis Fetal Care Institute in the post-MOMS trial era: hydrocephalus treatment outcomes (endoscopic third ventriculostomy versus ventriculo-peritoneal shunt).
        Childs Nerv Syst. 2017; 33 (In eng): 1157-1168
        • Partridge E.A.
        • Flake A.W.
        Maternal–fetal surgery for structural malformations.
        Best Pract Res Clin Obstet Gynaecol. 2012; 26: 669-682
        • Moise Jr., K.J.
        The history of fetal therapy.
        Am J Perinatol. 2014; 31 (In eng): 557-566
        • Benson C.B.
        • Doubilet P.M.
        The history of imaging in obstetrics.
        Radiology. 2014; 273 (In eng): S92-S110
        • Goldberg B.B.
        Obstetric US imaging: the past 40 years.
        Radiology. 2000; 215: 622-629
        • Newman P.G.
        • Rozycki G.S.
        The history of ultrasound.
        Surg Clin North Am. 1998; 78 (In eng): 179-195
        • Liley A.W.
        Diagnosis and treatment of erythroblastosis in the fetus.
        Adv Pediatr. 1968; 15 (In eng): 29-63
        • Pringle K.C.
        • Turner J.W.
        • Schofield J.C.
        • et al.
        Creation and repair of diaphragmatic hernia in the fetal lamb: lung development and morphology.
        J Pediatr Surg. 1984; 19 (In eng): 131-140
        • Harrison M.R.
        • Adzick N.S.
        • Bullard K.M.
        • et al.
        Correction of congenital diaphragmatic hernia in utero VII: a prospective trial.
        J Pediatr Surg. 1997; 32 (In eng): 1637-1642
        • Grivell R.M.
        • Andersen C.
        • Dodd J.M.
        Prenatal interventions for congenital diaphragmatic hernia for improving outcomes.
        Cochrane Database Syst Rev. 2015; 11 (In eng): Cd008925
        • Cole F.S.
        Fetal tracheal occlusion for congenital diaphragmatic hernia.
        N Engl J Med. 2021; https://doi.org/10.1056/nejme2107446
        • Copp A.J.
        • Adzick N.S.
        • Chitty L.S.
        • et al.
        Spina bifida.
        Nat Rev Dis Primers. 2015; 1: 15007
        • Mai C.T.
        • Isenburg J.L.
        • Canfield M.A.
        • et al.
        National population-based estimates for major birth defects, 2010-2014.
        Birth Defects Res. 2019; 111 (In eng): 1420-1435
        • Parker S.E.
        • Mai C.T.
        • Canfield M.A.
        • et al.
        Updated National Birth Prevalence estimates for selected birth defects in the United States, 2004-2006.
        Birth Defects Res A Clin Mol Teratol. 2010; 88 (In eng): 1008-1016
        • Moldenhauer J.S.
        • Flake A.W.
        Open fetal surgery for neural tube defects.
        Best Pract Res Clin Obstet Gynaecol. 2019; 58: 121-132
        • Attenello F.J.
        • Tuchman A.
        • Christian E.A.
        • et al.
        Infection rate correlated with time to repair of open neural tube defects (myelomeningoceles): an institutional and national study.
        Child's Nervous Syst. 2016; 32: 1675-1681
        • Cherian J.
        • Staggers K.A.
        • Pan I.W.
        • et al.
        Thirty-day outcomes after postnatal myelomeningocele repair: a National Surgical Quality Improvement Program Pediatric database analysis.
        J Neurosurg Pediatr. 2016; 18: 416-422
        • Adzick N.S.
        Fetal surgery for spina bifida: past, present, future.
        Semin Pediatr Surg. 2013; 22 (In eng): 10-17
        • Radmanesh F.
        • Nejat F.
        • Khashab M.E.
        • et al.
        Shunt complications in children with myelomeningocele: effect of timing of shunt placement.
        J Neurosurg Pediatr. 2009; 3: 516-520
        • Michejda M.
        Intrauterine treatment of spina bifida: primate model.
        Z Kinderchir. 1984; 39 (In eng): 259-261
        • Meuli M.
        • Meuli-Simmen C.
        • Yingling C.D.
        • et al.
        Creation of myelomeningocele in utero: a model of functional damage from spinal cord exposure in fetal sheep.
        J Pediatr Surg. 1995; 30 (; discussion 1032-3. (In eng)): 1028-1032
        • Yamashiro K.J.
        • Galganski L.A.
        • Hirose S.
        Fetal myelomeningocele repair.
        Semin Pediatr Surg. 2019; 28 (In eng): 150823
        • Meuli M.
        • Meuli-Simmen C.
        • Yingling C.D.
        • et al.
        In utero repair of experimental myelomeningocele saves neurological function at birth.
        J Pediatr Surg. 1996; 31 (In eng): 397-402
        • Bouchard S.
        • Davey M.G.
        • Rintoul N.E.
        • et al.
        Correction of hindbrain herniation and anatomy of the vermis after in utero repair of myelomeningocele in sheep.
        J Pediatr Surg. 2003; 38 (discussion 451-8. (In eng)): 451-458
        • Bruner J.P.
        • Tulipan N.E.
        • Richards W.O.
        Endoscopic coverage of fetal open myelomeningocele in utero.
        Am J Obstet Gynecol. 1997; 176 (In eng): 256-257
        • Tulipan N.
        • Bruner J.P.
        Myelomeningocele repair in utero: a report of three cases.
        Pediatr Neurosurg. 1998; 28: 177-180
        • Danzer E.
        • Thomas N.H.
        • Thomas A.
        • et al.
        Long-term neurofunctional outcome, executive functioning, and behavioral adaptive skills following fetal myelomeningocele surgery.
        Am J Obstet Gynecol. 2016; 214: 269.e1-269.e8
        • Mazzola C.A.
        • Assassi N.
        • Baird L.C.
        • et al.
        Congress of neurological surgeons systematic review and evidence-based guidelines for pediatric myelomeningocele: executive summary.
        Neurosurgery. 2019; 85: 299-301
        • Hilton S.A.
        • Hodges M.M.
        • Dewberry L.C.
        • et al.
        MOMS Plus: single-institution review of outcomes for extended BMI criteria for open fetal repair of myelomeningocele.
        Fetal Diagn Ther. 2019; 46 (In eng): 411-414
        • Moise Jr., K.J.
        • Moldenhauer J.S.
        • Bennett K.A.
        • et al.
        Current selection criteria and perioperative therapy used for fetal myelomeningocele surgery.
        Obstet Gynecol. 2016; 127 (In eng): 593-597
        • Sabbagh R.
        • Van den Veyver I.B.
        The current and future impact of genome-wide sequencing on fetal precision medicine.
        Hum Genet. 2020; 139 (In eng): 1121-1130
        • Santirocco M.
        • Plaja A.
        • Rodó C.
        • et al.
        Chromosomal microarray analysis in fetuses with central nervous system anomalies: an 8-year long observational study from a tertiary care university hospital.
        Prenatal Diagn. 2021; 41: 123-135
        • Bernhardt B.A.
        • Soucier D.
        • Hanson K.
        • et al.
        Women’s experiences receiving abnormal prenatal chromosomal microarray testing results.
        Genet Med. 2013; 15: 139-145
        • Kohl T.
        Percutaneous minimally invasive fetoscopic surgery for spina bifida aperta. Part I: surgical technique and perioperative outcome.
        Ultrasound Obstet Gynecol. 2014; 44 (In eng): 515-524
        • Kohl T.
        Impact of partial amniotic carbon dioxide insufflation (PACI) on middle cerebral artery blood flow in mid-gestation human fetuses undergoing fetoscopic surgery for spina bifida aperta.
        Ultrasound Obstet Gynecol. 2016; 47 (In eng): 521-522
        • Kohl T.
        Minimally invasive fetoscopic surgery for spina bifida aperta: learning and doing.
        Ultrasound Obstet Gynecol. 2020; 56 (In eng): 633
        • Sanz Cortes M.
        • Chmait R.H.
        • Lapa D.A.
        • et al.
        Experience of 300 cases of prenatal fetoscopic open spina bifida repair: report of the International Fetoscopic Neural Tube Defect Repair Consortium.
        Am J Obstet Gynecol. 2021; (In eng)https://doi.org/10.1016/j.ajog.2021.05.044
        • Kabagambe S.K.
        • Jensen G.W.
        • Chen Y.J.
        • et al.
        Fetal surgery for myelomeningocele: a systematic review and meta-analysis of outcomes in fetoscopic versus open repair.
        Fetal Diagn Ther. 2018; 43 (In eng): 161-174
        • Degenhardt J.
        • Schürg R.
        • Winarno A.
        • et al.
        Percutaneous minimal-access fetoscopic surgery for spina bifida aperta. Part II: maternal management and outcome.
        Ultrasound Obstet Gynecol. 2014; 44 (In eng): 525-531
        • Belfort M.A.
        • Whitehead W.E.
        • Shamshirsaz A.A.
        • et al.
        Fetoscopic repair of meningomyelocele.
        Obstet Gynecol. 2015; 126 (In eng): 881-884
        • Sanz Cortes M.
        • Lapa D.A.
        • Acacio G.L.
        • et al.
        Proceedings of the first annual meeting of the International Fetoscopic Myelomeningocele Repair Consortium.
        Ultrasound Obstet Gynecol. 2019; 53: 855-863
        • Belfort M.A.
        • Whitehead W.E.
        • Shamshirsaz A.A.
        • et al.
        Comparison of two fetoscopic open neural tube defect repair techniques: single- vs three-layer closure.
        Ultrasound Obstet Gynecol. 2020; 56 (In eng): 532-540
        • Alrefai A.
        • Drake J.
        • Kulkarni A.V.
        • et al.
        Fetal myelomeningocele surgery: only treating the tip of the iceberg.
        Prenatal Diagn. 2018; https://doi.org/10.1002/pd.5390
        • Moldenhauer J.S.
        • Adzick N.S.
        Fetal surgery for myelomeningocele: after the Management of Myelomeningocele Study (MOMS).
        Semin Fetal Neonatal Med. 2017; 22 (In eng): 360-366
        • Riddle S.
        • Huddle R.
        • Lim F.-Y.
        • et al.
        Morbidity and cost burden of prenatal myelomeningocele repair.
        J Maternal-Fetal Neonatal Med. 2021; 34: 1651-1657
        • Radcliff E.
        • Cassell C.H.
        • Tanner J.P.
        • et al.
        Hospital use, associated costs, and payer status for infants born with spina bifida.
        Birth Defects Res A Clin Mol Teratol. 2012; 94 (In eng): 1044-1053