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Review Article| Volume 49, ISSUE 1, P27-42, March 2022

Neonatal Hypertension

Published:January 21, 2022DOI:https://doi.org/10.1016/j.clp.2021.11.003

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      References

        • Singh H.P.
        • Hurley R.M.
        • Myers T.F.
        Neonatal hypertension: incidence and risk factors.
        Am J Hypertens. 1992; 5: 51-55
        • Blowey D.L.
        • Duda P.J.
        • Stokes P.
        • et al.
        Incidence and treatment of hypertension in the neonatal intensive care unit.
        J Am Soc Hypertens. 2011; 5: 478-483
        • Sahu R.
        • Pannu H.
        • Yu R.
        • et al.
        Systemic hypertension requiring treatment in the neonatal intensive care Unit.
        J Pediatr. 2013; 163: 84-88
        • Seliem W.A.
        • Falk M.C.
        • Shadbolt B.
        • et al.
        Antenatal and postnatal risk factors for neonatal hypertension and infant follow-up.
        Pediatr Nephrol. 2007; 22: 2081
        • Ravisankar S.
        • Kuehn D.
        • Clark R.H.
        • et al.
        Antihypertensive drug exposure in premature infants from 1997 to 2013.
        Cardiol Young. 2017; 27: 905-911
        • Kraut E.J.
        • Boohaker L.J.
        • Askenazi D.J.
        • et al.
        Incidence of neonatal hypertension from a large multicenter study (Assessment of Worldwide acute kidney injury Epidemiology in neonates—AWAKEN).
        Pediatr Res. 2018; 84: 279-289
        • Dionne J.M.
        • Abitbol C.L.
        • Flynn J.T.
        Hypertension in infancy: diagnosis, management and outcome.
        Pediatr Nephrol. 2011; 27: 17-32
        • Flynn J.T.
        • Kaelber D.C.
        • Baker-Smith C.M.
        • et al.
        Clinical practice guideline for screening and management of high blood pressure in children and adolescents.
        Pediatrics. 2017; 140: e20171904
        • Adelman R.D.
        Neonatal hypertension.
        Pediatr Clin North Am. 1978; 25: 99-110
        • Neal W.A.
        • Reynolds J.W.
        • Jarvis C.W.
        • et al.
        Umbilical artery catheterization: demonstration of arterial thrombosis by aortography.
        Pediatrics. 1972; 50: 6-13
        • Vailas G.N.
        • Brouillette R.T.
        • Scott J.P.
        • et al.
        Neonatal aortic thrombosis: recent experience.
        J Pediatr. 1986; 109: 101-108
        • Dionne J.M.
        Determinants of blood pressure in neonates and infants: predictable variability.
        Hypertension. 2021; 77: 781-787
        • Kent A.L.
        • Chaudhari T.
        Determinants of neonatal blood pressure.
        Curr Hypertens Rep. 2013; 15: 426-432
        • Sadoh W.E.
        • Ibhanesehbor S.E.
        • Monguno A.M.
        • et al.
        Predictors of newborn systolic blood pressure.
        West Afr J Med. 2010; 29: 86-90
        • Farnbach K.
        • Iragorri S.
        • Al-Uzri A.
        • et al.
        The changing spectrum of hypertension in premature infants.
        J Perinatol. 2019; 39: 1528-1534
        • Fridman A.L.
        • Hustead V.A.
        Hypertension in babies following discharge from a neonatal intensive care unit.
        Pediatr Nephrol. 1987; 1: 30-34
        • Selewski D.T.
        • Charlton J.R.
        • Jetton J.G.
        • et al.
        Neonatal acute kidney injury.
        Pediatrics. 2015; 136: e463-e473
        • Gilboa N.
        • Urizar R.E.
        Severe hypertension in newborn after pyeloplasty of hydronephrotic kidney.
        Urology. 1983; 22: 179-182
        • Moralıoğlu S.
        • Celayir A.C.
        • Bosnalı O.
        • et al.
        Single center experience in patients with unilateral multicystic dysplastic kidney.
        J Pediatr Urol. 2014; 10: 763-768
        • Boo N.
        • Wong N.
        • Zulkifli S.S.
        • et al.
        Risk factors associated with umbilical vascular catheter-associated thrombosis in newborn infants.
        J Paediatr Child Health. 1999; 35: 460-465
        • Seibert J.
        • Taylor B.
        • Williamson S.
        • et al.
        Sonographic detection of neonatal umbilical-artery thrombosis: clinical correlation.
        Am J Roentgenol. 1987; 148: 965-968
        • Barrington K.J.
        Umbilical artery catheters in the newborn: effects of position of the catheter tip.
        Cochrane Db Syst Rev. 1999; 1: CD000505
        • Marks S.D.
        • Massicotte M.P.
        • Steele B.T.
        • et al.
        Neonatal renal venous thrombosis: clinical outcomes and prevalence of prothrombotic disorders.
        J Pediatr. 2005; 146: 811-816
        • Lau K.K.
        • Stoffman J.M.
        • Williams S.
        • et al.
        Neonatal renal vein thrombosis: review of the English-language literature between 1992 and 2006.
        Pediatrics. 2007; 120: e1278-e1284
        • Tullus K.
        • Brennan E.
        • Hamilton G.
        • et al.
        Renovascular hypertension in children.
        Lancet. 2008; 371: 1453-1463
        • Izraelit A.
        • Kim M.
        • Ratner V.
        • et al.
        Mid-aortic syndrome in two preterm infants.
        J Perinatol. 2012; 32: 390-392
        • Peranteau W.H.
        • Tharakan S.J.
        • Partridge E.
        • et al.
        Systemic hypertension in giant omphalocele: an underappreciated association.
        J Pediatr Surg. 2015; 50: 1477-1480
        • Fujishiro J.
        • Sugiyama M.
        • Ishimaru T.
        • et al.
        Cyclic fluctuation of blood pressure in neonatal neuroblastoma.
        Pediatr Int. 2014; 56: 934-937
        • Jenkins R.D.
        • Aziz J.K.
        • Gievers L.L.
        • et al.
        Characteristics of hypertension in premature infants with and without chronic lung disease: a long-term multi-center study.
        Pediatr Nephrol. 2017; 32: 2115-2124
        • Abman S.H.
        Monitoring cardiovascular function in infants with chronic lung disease of prematurity.
        Arch Dis Child - Fetal Neonatal Ed. 2002; 87: F15
        • Sehgal A.
        • Malikiwi A.
        • Paul E.
        • et al.
        Systemic arterial stiffness in infants with bronchopulmonary dysplasia: potential cause of systemic hypertension.
        J Perinatol. 2016; 36: 564-569
        • Stroustrup A.
        • Bragg J.B.
        • Busgang S.A.
        • et al.
        Sources of clinically significant neonatal intensive care unit phthalate exposure.
        J Expo Sci Environ Epidemiol. 2020; 30: 137-148
        • Téllez-Rojo M.M.
        • Cantoral A.
        • Cantonwine D.E.
        • et al.
        Prenatal urinary phthalate metabolites levels and neurodevelopment in children at two and three years of age.
        Sci Total Environ. 2013; 461: 386-390
        • Kim Y.
        • Ha E.
        • Kim E.
        • et al.
        Prenatal exposure to phthalates and infant development at 6 months: prospective Mothers and children’s Environmental health (MOCEH) study.
        Environ Health Persp. 2011; 119: 1495-1500
        • Cho S.-C.
        • Bhang S.-Y.
        • Hong Y.-C.
        • et al.
        Relationship between environmental phthalate exposure and the intelligence of school-age children.
        Environ Health Persp. 2010; 118: 1027-1032
        • Fischer C.J.
        • Graz M.B.
        • Muehlethaler V.
        • et al.
        Phthalates in the NICU: is it safe?.
        J Paediatr Child H. 2013; 49: E413-E419
        • Jenkins R.
        • Tackitt S.
        • Gievers L.
        • et al.
        Phthalate-associated hypertension in premature infants: a prospective mechanistic cohort study.
        Pediatr Nephrol. 2019; 34: 1413-1424
        • Becker J.A.
        • Short B.L.
        • Martin G.R.
        Cardiovascular complications adversely affect survival during extracorporeal membrane oxygenation.
        Crit Care Med. 1998; 26: 1582-1586
        • Liviskie C.J.
        • DeAvilla K.M.
        • Zeller B.N.
        • et al.
        Nicardipine for the treatment of neonatal hypertension during extracorporeal membrane oxygenation.
        Pediatr Cardiol. 2019; 40: 1041-1045
        • Boedy R.F.
        • Goldberg A.K.
        • Howell C.G.
        • et al.
        Incidence of hypertension in infants on extracorporeal membrane oxygenation.
        J Pediatr Surg. 1990; 25: 258-261
        • Merritt J.C.
        • Kraybill E.N.
        Effect of mydriatics on blood pressure in premature infants.
        J Pediatr Ophthalmol Strabismus. 1981; 18: 42-46
        • Marinelli K.A.
        • Burke G.S.
        • Herson V.C.
        Effects of dexamethasone on blood pressure in premature infants with bronchopulmonary dysplasia.
        J Pediatr. 1997; 130: 594-602
        • Bailey N.A.
        • Diaz-Barbosa M.
        Effect of maternal substance abuse on the fetus, neonate, and child.
        Pediatr Rev. 2018; 39: 550-559
        • Horn P.T.
        Persistent hypertension after prenatal cocaine exposure.
        J Pediatr. 1992; 121: 288-291
        • Rodd C.
        • Goodyer P.
        Hypercalcemia of the newborn: etiology, evaluation, and management.
        Pediatr Nephrol. 1999; 13: 542
        • Nwankwo M.U.
        • Lorenz J.M.
        • Gardiner J.C.
        A standard protocol for blood pressure measurement in the newborn.
        Pediatrics. 1997; 99: e10
        • Dionne J.M.
        • Bremner S.A.
        • Baygani S.K.
        • et al.
        Method of blood pressure measurement in neonates and infants: a systematic review and analysis.
        J Pediatr. 2020; 221: 23-31.e5
        • Dionne J.M.
        • Flynn J.T.
        Management of severe hypertension in the newborn.
        Arch Dis Child. 2017; 102: 1176
        • Zubrow A.B.
        • Hulman S.
        • Kushner H.
        • et al.
        Determinants of blood pressure in infants admitted to neonatal intensive care units: a prospective multicenter study. Philadelphia Neonatal Blood Pressure Study Group.
        J Perinatol. 1995; 15: 470-479
        • Pejovic B.
        • Peco-Antic A.
        • Marinkovic-Eric J.
        Blood pressure in non-critically ill preterm and full-term neonates.
        Pediatr Nephrol. 2006; 22: 249-257
      1. Report of the second Task Force on blood pressure control in children--1987. Task Force on blood pressure control in children. National Heart, Lung, and Blood Institute, Bethesda, Maryland.
        Pediatrics. 1987; 79: 1-25
        • Lurbe E.
        • Garcia-Vicent C.
        • Torro I.
        • et al.
        First-year blood pressure increase steepest in low birthweight newborns.
        J Hypertens. 2007; 25: 81-86
        • Skalina M.
        • Kliegman R.
        • Fanaroff A.
        Epidemiology and management of severe symptomatic neonatal hypertension.
        Am J Perinatol. 1986; 3: 235-239
        • Louw J.
        • Brown S.
        • Eyskens B.
        • et al.
        Neonatal circulatory failure due to acute hypertensive crisis: clinical and echocardiographic clues.
        Cardiovasc J Afr. 2013; 24: 73-77
        • Xiao N.
        • Tandon A.
        • Goldstein S.
        • et al.
        Cardiogenic shock as the initial presentation of neonatal systemic hypertension.
        J Neonatal-perinatal Med. 2013; 6: 267-272
        • Crossland D.S.
        • Furness J.C.
        • Abu-Harb M.
        • et al.
        Variability of four limb blood pressure in normal neonates.
        Arch Dis Child - Fetal Neonatal Ed. 2004; 89: F325
        • Vo N.J.
        • Hammelman B.D.
        • Racadio J.M.
        • et al.
        Anatomic distribution of renal artery stenosis in children: implications for imaging.
        Pediatr Radiol. 2006; 36: 1032-1036
        • Daehnert I.
        • Hennig B.
        • Scheinert D.
        Percutaneous transluminal angioplasty for renovascular hypertension in a neonate.
        Acta Paediatr. 2005; 94: 1149-1152
        • Roth C.G.
        • Spottswood S.E.
        • Chan J.C.M.
        • et al.
        Evaluation of the hypertensive infant a rational approach to diagnosis.
        Radiol Clin North Am. 2003; 41: 931-944
        • Sulyok E.
        • Németh M.
        • Tényi I.
        • et al.
        Postnatal development of renin-angiotensin-aldosterone system, RAAS, in relation to electrolyte balance in premature infants.
        Pediatr Res. 1979; 13: 817-820
        • Ingelfinger J.R.
        Monogenic and polygenic contributions to hypertension.
        in: Flynn J.T. Ingelfinger J.R. Redwine K.R. Pediatric hypertension. 2018: 113-134
        • Perlman J.M.
        The relationship between systemic hemodynamic perturbations and periventricular-intraventricular hemorrhage: a historical perspective.
        Semin Pediatr Neurol. 2009; 16: 191-199
        • Rodieux F.
        • Wilbaux M.
        • van den Anker J.N.
        • et al.
        Effect of kidney function on drug kinetics and dosing in neonates, infants, and children.
        Clin Pharm. 2015; 54: 1183-1204
        • Flynn J.T.
        • Warnick S.J.
        Isradipine treatment of hypertension in children: a single-center experience.
        Pediatr Nephrol. 2002; 17: 748-753
        • Miyashita Y.
        • Peterson D.
        • Rees J.M.
        • et al.
        Isradipine for treatment of acute hypertension in hospitalized children and adolescents.
        J Clin Hypertens. 2010; 12: 850-855
        • Flynn J.T.
        • Pasko D.A.
        Calcium channel blockers: pharmacology and place in therapy of pediatric hypertension.
        Pediatr Nephrol. 2000; 15: 302-316
        • Kao L.C.
        • Durand D.J.
        • McCrea R.C.
        • et al.
        Randomized trial of long-term diuretic therapy for infants with oxygen-dependent bronchopulmonary dysplasia.
        J Pediatr. 1994; 124: 772-781
        • Snauwaert E.
        • Walle J.V.
        • Bruyne P.D.
        Therapeutic efficacy and safety of ACE inhibitors in the hypertensive paediatric population: a review.
        Arch Dis Child. 2017; 102: 63
        • Tack E.D.
        • Perlman J.M.
        Renal failure in sick hypertensive premature infants receiving captopril therapy.
        J Pediatr. 1988; 112: 805-810
        • Pandey R.
        • Koshy R.G.
        • Dako J.
        Angiotensin converting enzyme inhibitors induced acute kidney injury in newborn.
        J Maternal-fetal Neonatal Med. 2016; 30: 1-3
        • O’Dea R.F.
        • Mirkin B.L.
        • Alward C.T.
        • et al.
        Treatment of neonatal hypertension with captopril.
        J Pediatr. 1988; 113: 403-406
        • Tufro-McReddie A.
        • Romano L.M.
        • Harris J.M.
        • et al.
        Angiotensin II regulates nephrogenesis and renal vascular development.
        Am J Phy. 1995; 269: F110-F115
        • Frölich S.
        • Slattery P.
        • Thomas D.
        • et al.
        Angiotensin II-AT1–receptor signaling is necessary for cyclooxygenase-2–dependent postnatal nephron generation.
        Kidney Int. 2017; 91: 818-829
        • Ku L.C.
        • Zimmerman K.
        • Benjamin D.K.
        • et al.
        Safety of enalapril in infants admitted to the neonatal intensive care unit.
        Pediatr Cardiol. 2017; 38: 155-161
        • Gouyon J.B.
        • Geneste B.
        • Semama D.S.
        • et al.
        Intravenous nicardipine in hypertensive preterm infants.
        Arch Dis Child - Fetal Neonatal Ed. 1997; 76: F126
        • Treluyer J.M.
        • Hubert P.
        • Jouvet P.
        • et al.
        Intravenous nicardipine in hypertensive children.
        Eur J Pediatr. 1993; 152: 712-714
        • Milou C.
        • Debuche-Benouachkou V.
        • Semama D.S.
        • et al.
        Intravenous nicardipine as a first-line antihypertensive drug in neonates.
        Intensive Care Med. 2000; 26: 956-958
        • Flynn J.T.
        • Mottes T.A.
        • Brophy P.D.
        • et al.
        Intravenous nicardipine for treatment of severe hypertension in children.
        J Pediatr. 2001; 139: 38-43
        • Thomas C.
        • Svehla L.
        • Moffett B.S.
        Sodium nitroprusside induced cyanide toxicity in pediatric patients.
        Expert Opin Drug Saf. 2009; 8: 599-602
        • Benitz W.E.
        • Malachowski N.
        • Cohen R.S.
        • et al.
        Use of sodium nitroprusside in neonates: efficacy and safety.
        J Pediatr. 1985; 106: 102-110
        • Tabbutt S.
        • Nicolson S.C.
        • Adamson P.C.
        • et al.
        The safety, efficacy, and pharmacokinetics of esmolol for blood pressure control immediately after repair of coarctation of the aorta in infants and children: a multicenter, double-blind, randomized trial.
        J Thorac Cardiovasc Surg. 2008; 136: 321-328
        • Thomas C.A.
        • Moffett B.S.
        • Wagner J.L.
        • et al.
        Safety and efficacy of intravenous labetalol for hypertensive crisis in infants and small children.
        Pediatr Crit Care Me. 2011; 12: 28-32
        • Rajpoot D.K.
        • Duel B.
        • Thayer K.
        • et al.
        Medically resistant neonatal hypertension: revisiting the surgical causes.
        J Perinatol. 1999; 19: 582-583
        • Bendel-Stenzel M.
        • Najarian J.S.
        • Sinaiko A.R.
        Renal artery stenosis in infants: long-term medical treatment before surgery.
        Pediatr Nephrol. 1996; 10: 147-151
        • Kiessling S.G.
        • Wadhwa N.
        • Kriss V.M.
        • et al.
        An unusual case of severe therapy-resistant hypertension in a newborn.
        Pediatrics. 2007; 119: e301-e304
        • Abdulhannan P.
        • Stahlschmidt J.
        • Subramaniam R.
        Multicystic dysplastic kidney disease and hypertension: clinical and pathological correlation.
        J Pediatr Urol. 2011; 7: 566-568
        • Sheftel D.N.
        • Hustead V.
        • Friedman A.
        Hypertension screening in the follow-up of premature infants.
        Pediatrics. 1983; 71: 763-766
        • Buchi K.F.
        • Siegler R.L.
        Hypertension in the first month of life.
        J Hypertens. 1986; 4: 525-528
        • Xiao N.
        • Hamdani G.
        • Michelle S.
        • et al.
        SAT-318 blood pressure outcomes in neonatal intensive care unit graduates with idiopathic hypertension.
        Kidney Int Rep. 2019; 4: S141
        • Mocan H.
        • Beattie T.J.
        • Murphy A.V.
        Renal venous thrombosis in infancy: long-term follow-up.
        Pediatr Nephrol. 1991; 5: 45-49
        • Ouellette A.C.
        • Darling E.K.
        • Sivapathasundaram B.
        • et al.
        Incidence, risk factors, and outcomes of neonatal renal vein thrombosis in Ontario: population-based cohort study.
        Kidney360. 2020; 1: 640-647
        • O’Sullivan J.J.
        • Derrick G.
        • Darnell R.
        Prevalence of hypertension in children after early repair of coarctation of the aorta: a cohort study using casual and 24 hour blood pressure measurement.
        Heart. 2002; 88: 163
        • Sutherland M.R.
        • Bertagnolli M.
        • Lukaszewski M.-A.
        • et al.
        Preterm birth and hypertension risk.
        Hypertension. 2014; 63: 12-18
        • Sutherland M.
        • Ryan D.
        • Black M.J.
        • et al.
        Long-term renal consequences of preterm birth.
        Clin Perinatol. 2014; 41: 561-573
        • Greenberg J.H.
        • McArthur E.
        • Thiessen-Philbrook H.
        • et al.
        Long-term risk of hypertension after surgical repair of congenital heart disease in children.
        JAMA Netw Open. 2021; 4: e215237
        • Bao W.
        • Threefoot S.A.
        • Srinivasan S.R.
        • et al.
        Essential hypertension predicted by tracking of elevated blood pressure from childhood to adulthood: the Bogalusa heart study.
        Am J Hypertens. 1995; 8: 657-665