Advertisement
Review Article| Volume 49, ISSUE 1, P1-14, March 2022

Delirium in the Neonate

Published:January 21, 2022DOI:https://doi.org/10.1016/j.clp.2021.11.001

      Keywords

      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'

      Subscribers receive full online access to your subscription and archive of back issues up to and including 2002.

      Content published before 2002 is available via pay-per-view purchase only.

      Subscribe:

      Subscribe to Clinics in Perinatology
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect

      References

        • American Psychiatric Association., American Psychiatric Association. DSM-5 Task Force
        Diagnostic and statistical manual of mental disorders : DSM-5.
        5th edition. American Psychiatric Association, Washington, DC2013
        • Harris J.
        • Ramelet A.S.
        • van Dijk M.
        • et al.
        Clinical recommendations for pain, sedation, withdrawal and delirium assessment in critically ill infants and children: an ESPNIC position statement for healthcare professionals.
        Intensive Care Med. 2016; 42: 972-986
        • Silver G.
        • Kearney J.
        • Traube C.
        • et al.
        Delirium screening anchored in child development: the Cornell assessment for pediatric delirium.
        Palliat Support Care. 2015; 13: 1005-1011
        • Liviskie C.
        • McPherson C.
        Delirium in the NICU: risk or reality?.
        Neonatal Netw. 2021; 40: 103-112
        • Groves A.
        • Traube C.
        • Silver G.
        Detection and management of delirium in the neonatal unit: a case series.
        Pediatrics. 2016; 137: e20153369
        • Brahmbhatt K.
        • Whitgob E.
        Diagnosis and management of delirium in critically ill infants: case report and review.
        Pediatrics. 2016; 137: e20151940
        • Edwards L.E.
        • Hutchison L.B.
        • Hornik C.D.
        • et al.
        A case of infant delirium in the neonatal intensive care unit.
        J Neonatal Perinatal Med. 2017; 10: 119-123
        • Madden K.
        • Turkel S.
        • Jacobson J.
        • et al.
        Recurrent delirium after surgery for congenital heart disease in an infant.
        Pediatr Crit Care Med. 2011; 12: e413-e415
        • Smith H.A.
        • Brink E.
        • Fuchs D.C.
        • et al.
        Pediatric delirium: monitoring and management in the pediatric intensive care unit.
        Pediatr Clin North Am. 2013; 60: 741-760
        • Traube C.
        • Silver G.
        • Gerber L.M.
        • et al.
        Delirium and mortality in critically ill children: epidemiology and outcomes of pediatric delirium.
        Crit Care Med. 2017; 45: 891-898
        • Dervan L.A.
        • Di Gennaro J.L.
        • Farris R.W.D.
        • et al.
        Delirium in a Tertiary PICU: risk factors and outcomes.
        Pediatr Crit Care Med. 2020; 21: 21-32
        • Traube C.
        • Silver G.
        • Reeder R.W.
        • et al.
        Delirium in critically ill children: an international point prevalence study.
        Crit Care Med. 2017; 45: 584-590
        • Maldonado J.R.
        Neuropathogenesis of delirium: review of current etiologic theories and common pathways.
        Am J Geriatr Psychiatry. 2013; 21: 1190-1222
        • Traube C.
        • Silver G.
        • Kearney J.
        • et al.
        Cornell Assessment of Pediatric Delirium: a valid, rapid, observational tool for screening delirium in the PICU.
        Crit Care Med. 2014; 42: 656-663
        • Patel A.K.
        • Bell M.J.
        • Traube C.
        Delirium in pediatric critical care.
        Pediatr Clin North Am. 2017; 64: 1117-1132
        • Slooff V.D.
        • van den Dungen D.K.
        • van Beusekom B.S.
        • et al.
        Monitoring haloperidol plasma concentration and associated adverse events in critically ill children with delirium: first results of a clinical protocol aimed to monitor efficacy and safety.
        Pediatr Crit Care Med. 2018; 19: e112-e119
        • Schieveld J.N.
        • Leroy P.L.
        • van Os J.
        • et al.
        Pediatric delirium in critical illness: phenomenology, clinical correlates and treatment response in 40 cases in the pediatric intensive care unit.
        Intensive Care Med. 2007; 33: 1033-1040
        • Capino A.C.
        • Thomas A.N.
        • Baylor S.
        • et al.
        Antipsychotic use in the prevention and treatment of intensive care unit delirium in pediatric patients.
        J Pediatr Pharmacol Ther. 2020; 25: 81-95
        • Joyce C.
        • Witcher R.
        • Herrup E.
        • et al.
        Evaluation of the safety of quetiapine in treating delirium in critically ill children: a retrospective review.
        J Child Adolesc Psychopharmacol. 2015; 25: 666-670
        • Campbell C.T.
        • Grey E.
        • Munoz-Pareja J.
        • et al.
        An evaluation of risperidone dosing for pediatric delirium in children less than or equal to 2 years of age.
        Ann Pharmacother. 2020; 54: 464-469
        • Carrasco G.
        • Baeza N.
        • Cabre L.
        • et al.
        Dexmedetomidine for the treatment of hyperactive delirium refractory to haloperidol in nonintubated ICU patients: a nonrandomized controlled trial.
        Crit Care Med. 2016; 44: 1295-1306
        • Reade M.C.
        • O'Sullivan K.
        • Bates S.
        • et al.
        Dexmedetomidine vs. haloperidol in delirious, agitated, intubated patients: a randomised open-label trial.
        Crit Care. 2009; 13: R75
      1. (U.S.). NLoM. Effects of Dexmedetomidine on Delirium Duration of Non-intubated ICU Patients (4D Trial). In: Available at: https://ClinicalTrials.gov/show/NCT03317067. Accessed June 22, 2021.

        • Louis C.
        • Godet T.
        • Chanques G.
        • et al.
        Effects of dexmedetomidine on delirium duration of non-intubated ICU patients (4D trial): study protocol for a randomized trial.
        Trials. 2018; 19: 307
        • O'Mara K.
        • Gal P.
        • Wimmer J.
        • et al.
        Dexmedetomidine versus standard therapy with fentanyl for sedation in mechanically ventilated premature neonates.
        J Pediatr Pharmacol Ther. 2012; 17: 252-262
        • Abdi H.H.
        • Maitre N.L.
        • Benninger K.L.
        • et al.
        Gabapentin use for hospitalized neonates.
        Pediatr Neurol. 2019; 97: 64-70
        • Edwards L.
        • DeMeo S.
        • Hornik C.D.
        • et al.
        Gabapentin use in the neonatal intensive care unit.
        J Pediatr. 2016; 169: 310-312
        • Sills G.J.
        The mechanisms of action of gabapentin and pregabalin.
        Curr Opin Pharmacol. 2006; 6: 108-113
        • Pinto Filho W.A.
        • Silveira L.H.J.
        • Vale M.L.
        • et al.
        Gabapentin in improvement of procedural sedation and analgesia in oncologic pediatric patients: a clinical trial.
        Anesth Pain Med. 2019; 9: e91197
        • Badawy A.A.
        • Kasem S.A.
        • Rashwan D.
        • et al.
        The role of Gabapentin oral solution in decreasing desflurane associated emergence agitation and delirium in children after stabismus surgery, a prospective randomized double-blind study.
        BMC Anesthesiol. 2018; 18: 73
        • Laudone T.W.
        • Beck S.D.
        • Lahr H.J.
        Evaluation of melatonin practices for delirium in pediatric critically ill patients.
        J Pediatr Pharmacol Ther. 2021; 26: 361-365
        • Parvataneni T.
        • Srinivas S.
        • Shah K.
        • et al.
        Perspective on melatonin use for sleep problems in autism and attention-deficit hyperactivity disorder: a systematic review of randomized clinical trials.
        Cureus. 2020; 12: e8335
        • Calandriello A.
        • Tylka J.C.
        • Patwari P.P.
        Sleep and delirium in pediatric critical illness: what is the relationship?.
        Med Sci (Basel). 2018; 6
        • Mason K.P.
        Paediatric emergence delirium: a comprehensive review and interpretation of the literature.
        Br J Anaesth. 2017; 118: 335-343
      2. ( U.S.). NLoM. Efficacy of quetiapine for pediatric delirium. 2015-2016.
        (Available at:) (Accessed June 23, 2021)
      3. ( U.S.). NLoM. Quetiapine treatment for pediatric delirium. 2019-2020.
        (Available at:) (Accessed June 23, 2021)
        • Egbuta C.
        • Mason K.P.
        Current state of analgesia and sedation in the pediatric intensive care unit.
        J Clin Med. 2021; 10: 1847
        • Scarpi E.
        • Maltoni M.
        • Miceli R.
        • et al.
        Survival prediction for terminally ill cancer patients: revision of the palliative prognostic score with incorporation of delirium.
        Oncologist. 2011; 16: 1793-1799
        • Shehabi Y.
        • Riker R.R.
        • Bokesch P.M.
        • et al.
        Delirium duration and mortality in lightly sedated, mechanically ventilated intensive care patients.
        Crit Care Med. 2010; 38: 2311-2318