Ingesting live bacteria on an ongoing basis to improve health seems rather counter-intuitive.
Nevertheless, this practice is precisely the basis for a rapidly developing area of
medical therapeutics. This article discusses the pathophysiology of this unusual therapeutic
approach, reviews existing clinical data, particularly as they relate to the premature
intestine, and considers some of the theoretical concerns for the future.
To read this article in full you will need to make a payment
Purchase one-time access:
Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online accessOne-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribers receive full online access to your subscription and archive of back issues up to and including 2002.
Content published before 2002 is available via pay-per-view purchase only.
Subscribe:
Subscribe to Clinics in PerinatologyAlready a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
References
- Volatile fatty acids, lactic acid, and pH in the stools of breast-fed and bottle-fed infants.J Pediatr Gastroenterol Nutr. 1991; 15: 248-252
- Development of the intestinal flora in very low birthweight infants compared to normal full-term newborns.Eur J Pediatr. 1985; 114: 186-190
- Stool microflora in extremely low birthweight infants.Arch Dis Child Fetal Neonatal Ed. 1999; 80: F167-F173
- Interactions mediating bacterial translocation in the immature intestine.J Nutr. 2000; 130: 432S-436S
- Escherichia coli trancytosis in a caco-2 cell model: implications in neonatal necrotizing enterocolitis.Pediatr Res. 1996; 40: 415-421
- Production of class II bacteriocins by lactic acid bacteria; an example of biological warfare and communication.Antonie Van Leeuwenhoek. 2002; 81: 639-654
- Probiotics: growth promoting factors produced by microorganisms.Science. 1965; 147: 747-748
- Clinical uses of probiotics for stabilizing the gut mucosal barrier: successful strains and future challenges.Antonie Van Leeuwenhoek. 1996; 70: 347-358
- Enteral feeding of premature infants with Lactobacillus GG.Arch Dis Child. 1993; 69: 483-487
- Lack of gastrointestinal bacterial colonization in premature infants.Pediatr Infect Dis J. 1986; 5: 663-668
- Effects of feeding premature infants with Lactobacillus LGG on gut fermentation.Arch Dis Child. 1993; 69: 488-492
- Transient colonization of the gut of newborn infants by orally administered bifidobacteria and lactobacilli.Acta Pediatr. 1992; 81: 784-787
- Effects of oral Lactobacillus GG on enteric microflora in low-birth-weight neonates.J Pediatr Gastroenterol Nutr. 2003; 36: 397-402
- Lactobacillus therapy for acute infectious diarrhea in children: a meta-analysis.Pediatrics. 2002; 109: 678-684
- Probiotics in the treatment and prevention of acute infectious diarrhea in infants and children: a systematic review of published randomized, double-blind, placebo-controlled trials.J Pediatr Gastroenterol Nutr. 2001; 33: S17-S25
- Lactobacillus GG administered in oral rehydration solution to children with acute diarrhea: a multicenter European trial.J Pediatr Gastroenterol Nutr. 2000; 30: 54-60
- Probiotics and infectious diarrhea.Am J Gastroenterol. 2000; 95: S16-S18
- Probiotics, antibiotic-associated diarrhoea and Clostridium difficile diarrhoea in humans.Best Pract Res Clin Gastroenterol. 2003; 17: 775-783
- Feeding of Bifidobacterium bifidum and Streptococcus thermophilus to infants in hospital for prevention of diarrhoea and shedding of rotavirus.Lancet. 1994; 344: 1046-1049
- Efficacy of Lactobacillus GG in prevention of nosocomial diarrhea in infants.J Pediatr. 2001; 138: 361-365
- Role of bacterial adherence and the mucous barrier on bacterial translocation.Ann Surg. 1997; 225: 317-326
- Enteric colonization in sporadic neonatal necrotizing enterocolitis.J Pediatr Gastroenterol Nutr. 1985; 4: 591-595
- Evaluation of gastrointestinal microflora in necrotizing enterocolitis.J Pediatr. 1978; 92: 589-591
- Endemic necrotizing enterocolitis: lack of association with a specific infectious agent.Pediatr Infect Dis J. 1994; 13: 725-734
- Quantitative changes in faecal microflora preceding necrotising enterocolitis in premature neonates.Arch Dis Child. 1990; 65: 1057-1059
- Immune responses in rhesus rotavirus-challenged Balb/c mice treated with bifidobacteria and prebiotic supplements.Pediatr Res. 2002; 51: 750-755
- Evaluation of probiotic treatment in a neonatal animal model.Pediatr Surg Int. 2000; 16: 237-242
- Bifidobacterial supplementation reduces the incidence of necrotizing enterocolitis in a neonatal rat model.Gastroenterology. 1999; 117: 577-583
- Oligofructose and experimental model of neonatal necrotising enterocolitis.Br J Nutr. 2002; 87: S213-S219
- Breast milk and neonatal enterocolitis.Lancet. 1990; 336: 1519-1523
- Early administration of Bifidobacterium breve to preterm infants: randomised controlled trial.Arch Dis Child Fetal Neonatal Ed. 1997; 76: F101-F107
- Probiotics feeding in prevention of urinary tract infection, bacterial sepsis and necrotizing enterocolitis in preterm infants.Biol Neonate. 2002; 82: 103-108
- Lactobacillus GG supplementation does not reduce faecal colonization of Klebsiella oxytoca in preterm infants.Acta Paediatr. 1997; 86: 785-786
- Reduced incidence of necrotizing enterocolitis associated with enteral administration of Lactobacillus acidophilus and Bifidobacterium infantis to neonates in an intensive care unit.Int J Infect Dis. 1999; 3: 197-202
- Germ warfare: probiotic prophylaxis protects against feeding difficulties in premature neonates [abstract].Pediatr Res. 2003; 53: 438a
- Use of lactulose to create a preponderance of lactobacilli in the intestine of bottle-fed infants.Scot Med J. 1959; 4: 182-189
- Probiotics plus antibiotics: regulating our bacterial environment.J Pediatr. 1999; 135: 535-537
- Demonstration of safety of probiotics-a review.Int J Food Microbiol. 1998; 44: 93-106
- Lactobacillus bacteremia and endocarditis: review of 45 cases.Clin Infect Dis. 1997; 25: 1048-1055
- Lactobacillus acidophilus sepsis in a neonate.J Perinatol. 2001; 21: 258-260
- Neonatal meningitis due to Lactobacillus.Pediatr Infect Dis. 1983; 2: 382-384
- Lactobacillus rhamnosus infection in a child following bone marrow transplant.J Infect. 1996; 32: 165-167
- Isolation of non-sporing anaerobic rods from infections in children.J Med Microbiol. 1996; 45: 21-26
- Safety of probiotics that contain lactobacilli or bifidobacteria.Clin Infect Dis. 2003; 36: 775-780
- Lactobacillus endocarditis caused by a probiotic organism.Clin Microbiol Infect. 1999; 5: 290-292
- Possible role of catheters in Saccharomyces boulardii fungemia.Eur J Clin Microbiol Infect Dis. 2000; 19: 16-20
- Probiotic bacteria in dietetic products for infants: a commentary by the ESPGHAN Committee on Nutrition (medical position paper).J Pediatr Gastroenterol Nutr. 2004; 38: 365-374
- Microbiologic evaluation of commercial probiotics.J Am Vet Med Assoc. 2002; 15: 794-797
- Long-term consumption of infant formulas containing live probiotic bacteria: tolerance and safety.Am J Clin Nutr. 2004; 79: 261-267
- Commensal host bacterial relationships in the gut.Science. 2001; 292: 1115-1118
- Gastrointestinal effects of prebiotics.Br J Nutr. 2002; 87: S145-S151
- Supplementation of a bovine milk formula with an oligosaccharide mixture increases counts of faecal bifidobacteria in preterm infants.Arch Dis Child Fetal Neonatal Ed. 2002; 86: F178-F181
Article info
Identification
Copyright
© 2004 Elsevier Inc. Published by Elsevier Inc. All rights reserved.